The synthetic amino acid trans-4-aminomethylcyclohexanecarboxylic acid, also known as epsilon-aminocaproic acid or trans-4-aminomethylcyclohexanecarboxylic acid, has long exceeded hemostasis as its sole purpose in medicine. Researchers have recently shown that Tranexamic acid powder has significant potential for treating a wide variety of diseases and improving skin conditions, based on in-depth research into its non-hemostatic effects. Transexamic acid is reviewed in this article in terms of its non-hemostatic effects and mechanisms, as well as its innovative clinical applications, aimed at providing new methods for its clinical application.
Tranexamic acid's non-hemostatic effects and mechanisms
Protection of mitochondria
By enhancing mitochondrial markers, strengthening mitochondrial respiratory capacity, inhibiting mitochondrial autophagy and mitochondrial DNA release, transexamic acid effectively protects mitochondria from damage caused by external factors such as UV rays. Using tranexamic acid as a treatment for mitochondrial dysfunction offers new opportunities.
Effects on bacteria and viruses
As a result of reducing protein and polysaccharide components in biofilms, transexamic acid inhibits bacterial biofilm formation and suppresses bacterial growth by altering the duration of the lag phase, the rate of exponential growth, and the density of bacteria. Furthermore, it is antiviral against viruses like the dengue virus DP1. These findings suggest that tranexamic acid has potential for preventing and treating infectious diseases.
Effects on cancer
By inhibiting protein synthesis and reducing histone acetylation, transexamic acid displays anticancer activity by regulating plasmin/macrophage/interleukin-6/transcription factor 3/cyclin D signaling pathways, thus reducing the viability of various cancer cell lines. Transexamic acid can now be used to treat tumors in new ways.
Benefits of anti-aging
By inhibiting plasmin synthesis, reducing kinin production, and lowering levels of reactive oxygen species, interleukin-6, matrix metalloproteinase-9, and tumor necrosis factor-α in the blood, tranexamic acid suppresses inflammatory reactions and the occurrence of aging-related diseases, significantly extending the lifespan of mice. This provides a scientific basis for the application of tranexamic acid in the field of anti-aging.
Skin Disease Treatment
The treatment of acne, rosacea, melasma, psoriasis, and post-inflammatory hyperpigmentation has been demonstrated to be extremely effective with tranexamic acid. This drug has broad dermatological applications due to its anti-inflammatory effects, inhibition of angiogenesis, and reduction of melanin production.
Tranexamic acid: Innovations in Clinical Application
Methods for regulating drugs
The traditional method of administering tranexamic acid is through oral or injection routes, which can result in systemic side effects and pain. Skin disease treatments have gradually moved from topical solutions to topical creams in recent years. Transdermal administration of tranexamic acid has also been improved by the study of novel drug delivery systems like soluble microneedles.
Derivatives Development
It is possible to prepare derivatives of tranexamic acid that are more bioavailable and more effective by chemically modifying the amino or carboxyl groups. Aside from improving the transdermal permeability of tranexamic acid, these derivatives also enhance its efficacy or confer new efficacy, providing a wider range of clinical applications for this drug.
Prospects and Discussion
A multifunctional drug, tranexamic acid exhibits significant potential in several areas. However, optimization of administration methods, stability, and safety of derivatives remain challenges for its clinical application. Developing safer and more effective drug delivery systems and derivatives, as well as expanding tranexamic acid's clinical applications, should be the focus of future research. It is also necessary to conduct tranexamic acid synergy research in conjunction with other drugs so that tranexamic acid can be used in treatment of complex diseases in a synergistic manner. Get more info about Cosmetic Raw Materials Manufacturer.
In conclusion
As a synthetic amino acid, tranexamic acid not only possess hemostatic effects but also demonstrate significant non-hemostatic effects in mitochondrial protection, antibacterial and antiviral activity, anticancer activity, antiaging, and treatment of skin diseases. Transexamic acid is expected to play an important role in a variety of fields with in-depth research into its mechanisms of action and innovations in clinical applications.
